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Beyond their function of preventing water loss, cuticular lipids are also used as communication signals in symbioses involving ants, butterflies and plants. Abstract: Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects.

Cuticular compounds can enable interactions directly acting as allomones, or indirectly as kairomones or synomones. The esters analogs of dexibuprofen 5a–c were obtained by reacting its –COOH group with chloroacetyl derivatives 3a–c.

We characterized a new BRCA1 variant discovered in a breast cancer patient during BRCA1/2 screening by next-generation sequencing.

Bioinformatic predictions; indicating that the variant is probably pathogenetic; were verified using retro-transcription of the patient’s RNA followed by PCR amplifications performed on the resulting c DNA.

The platelet rich plasma was obtained from the blood 90 min after prodrugs (100 mg/kg) were orally administered into Sprague-Dawley (SD) rats, and platelet aggregation was induced by adenosinediphosphate (ADP) (1.3 µmol/L) or collagen (32.8 µg/m L), Significant at *** = ) with receptor.

Lastly; these data reinforce the importance of studying the effects of sequence variants at the RNA level to verify their potential role in disease onset.

gene exon-intron structure and the variant localization is reported in the top panel.

Full article "Abstract: High dose glucocorticoid (GC) administration impairs the viability and function of osteoblasts, thus causing osteoporosis and osteonecrosis.

Neuropeptide Y1 receptor (Y1 receptor) is expressed in bone tissues and cells, and regulates bone remodeling.

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