And non sedating

If the heart rate is uneven or fast, or if the patient is shaking and weak, the medication should be stopped and the patient's physician notified immediately.

Antihistamines: Drugs that combat the histamine released during an allergic reaction by blocking the action of the histamine on the tissue.

Inducible urticarias include all forms of physical urticarias (cold-induced, heat-induced, solar, and pressure urticaria).

According to the International Guidelines for the management of urticaria and angioedema non-sedating, second generation antihistamines (NSAHs) are recommended for the treatment of CU [].

Antihistamines frequently cause mouth dryness and sleepiness.

Newer non-sedating antihistamines are generally thought to be somewhat less effective.

Many patients are most familiar with antihistamines used to treat respiratory allergies such as hay fever or as an ingredient in over-the-counter sleeping pills.

Others antihistamines, such as meclizine, are often prescribed to prevent the vertigo and nausea that accompany motion sickness.

Urticaria and angioedema lasting more than 6 weeks have been designated as chronic urticaria (CU).

The present article is a review of the literature on the treatment of CU with increased doses of NSAHs in order to investigate if there are differences in efficacy between the various second generation AHs that have been studied in controlled protocols.

It must be noticed, however, that it is difficult to find clinical investigations that strictly follow the criteria recommended by the guidelines on the management of urticaria, and therefore studies included in this review were those in which higher doses of NSAHs were used regardless of the clinical response to conventional doses.

Antihistamines do not stop the formation of histamine nor do they stop the conflict between the Ig E and antigen.

Therefore, antihistamines do not stop the allergic reaction but protect tissues from some of its effects.

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